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SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice

Excessive production of reactive oxygen species (ROS) contributes to progression of atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory activation. The class III histone deacetylase SIRT1 has been implicated in extension of lifespan. In the vasculature,SIRT1 gain-of...

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Detalles Bibliográficos
Autores principales:	Stein, Sokrates, Schäfer, Nicola, Breitenstein, Alexander, Besler, Christian, Winnik, Stephan, Lohmann, Christine, Heinrich, Kathrin, Brokopp, Chad E., Handschin, Christoph, Landmesser, Ulf, Tanner, Felix C., Lüscher, Thomas F., Matter, Christian M.
Formato:	Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919255/ https://www.ncbi.nlm.nih.gov/pubmed/20606253

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