Sestrins at the crossroad between stress and aging

Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging a...

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Detalles Bibliográficos
Autores principales: Lee, Jun Hee, Bodmer, Rolf, Bier, Ethan, Karin, Michael
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919257/
https://www.ncbi.nlm.nih.gov/pubmed/20606249
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author Lee, Jun Hee
Bodmer, Rolf
Bier, Ethan
Karin, Michael
author_facet Lee, Jun Hee
Bodmer, Rolf
Bier, Ethan
Karin, Michael
author_sort Lee, Jun Hee
collection PubMed
description Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.
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spelling pubmed-29192572010-08-12 Sestrins at the crossroad between stress and aging Lee, Jun Hee Bodmer, Rolf Bier, Ethan Karin, Michael Aging (Albany NY) Research Perspective Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints. Impact Journals LLC 2010-06-13 /pmc/articles/PMC2919257/ /pubmed/20606249 Text en Copyright: ©2010 Lee et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Perspective
Lee, Jun Hee
Bodmer, Rolf
Bier, Ethan
Karin, Michael
Sestrins at the crossroad between stress and aging
title Sestrins at the crossroad between stress and aging
title_full Sestrins at the crossroad between stress and aging
title_fullStr Sestrins at the crossroad between stress and aging
title_full_unstemmed Sestrins at the crossroad between stress and aging
title_short Sestrins at the crossroad between stress and aging
title_sort sestrins at the crossroad between stress and aging
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919257/
https://www.ncbi.nlm.nih.gov/pubmed/20606249
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AT karinmichael sestrinsatthecrossroadbetweenstressandaging

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