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Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine
The hydrochloride of the racemic amino acid (7-hydroxycoumarin-4-yl)ethylglycine, a versatile fluorescent probe in proteins, has been synthesized in five steps from commercially available (7-hydroxycoumarin-4-yl)acetic acid. The key step involves the alkylation of a glycine–enolate equivalent.
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| Formato: | Texto |
| Lenguaje: | English |
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Beilstein-Institut
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919258/ https://www.ncbi.nlm.nih.gov/pubmed/20703371 http://dx.doi.org/10.3762/bjoc.6.69 |
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| author | Braun, Manfred Dittrich, Torsten |
| author_facet | Braun, Manfred Dittrich, Torsten |
| author_sort | Braun, Manfred |
| collection | PubMed |
| description | The hydrochloride of the racemic amino acid (7-hydroxycoumarin-4-yl)ethylglycine, a versatile fluorescent probe in proteins, has been synthesized in five steps from commercially available (7-hydroxycoumarin-4-yl)acetic acid. The key step involves the alkylation of a glycine–enolate equivalent. |
| format | Text |
| id | pubmed-2919258 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | Beilstein-Institut |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29192582010-08-11 Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine Braun, Manfred Dittrich, Torsten Beilstein J Org Chem Full Research Paper The hydrochloride of the racemic amino acid (7-hydroxycoumarin-4-yl)ethylglycine, a versatile fluorescent probe in proteins, has been synthesized in five steps from commercially available (7-hydroxycoumarin-4-yl)acetic acid. The key step involves the alkylation of a glycine–enolate equivalent. Beilstein-Institut 2010-06-24 /pmc/articles/PMC2919258/ /pubmed/20703371 http://dx.doi.org/10.3762/bjoc.6.69 Text en Copyright © 2010, Braun and Dittrich https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
| spellingShingle | Full Research Paper Braun, Manfred Dittrich, Torsten Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine |
| title | Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine |
| title_full | Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine |
| title_fullStr | Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine |
| title_full_unstemmed | Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine |
| title_short | Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine |
| title_sort | synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine |
| topic | Full Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919258/ https://www.ncbi.nlm.nih.gov/pubmed/20703371 http://dx.doi.org/10.3762/bjoc.6.69 |
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