Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring

We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety. Preparation of the aminopiperidine intermediate was carried out by constructing the cyclopropyl ring...

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Detalles Bibliográficos
Autores principales: Kodimuthali, Arumugam, Prasunamba, Padala Lakshmi, Pal, Manojit
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2010
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919267/
https://www.ncbi.nlm.nih.gov/pubmed/20703380
http://dx.doi.org/10.3762/bjoc.6.71
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author Kodimuthali, Arumugam
Prasunamba, Padala Lakshmi
Pal, Manojit
author_facet Kodimuthali, Arumugam
Prasunamba, Padala Lakshmi
Pal, Manojit
author_sort Kodimuthali, Arumugam
collection PubMed
description We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety. Preparation of the aminopiperidine intermediate was carried out by constructing the cyclopropyl ring prior to assembling the piperidine ring.
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spelling pubmed-29192672010-08-11 Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring Kodimuthali, Arumugam Prasunamba, Padala Lakshmi Pal, Manojit Beilstein J Org Chem Preliminary Communication We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety. Preparation of the aminopiperidine intermediate was carried out by constructing the cyclopropyl ring prior to assembling the piperidine ring. Beilstein-Institut 2010-07-01 /pmc/articles/PMC2919267/ /pubmed/20703380 http://dx.doi.org/10.3762/bjoc.6.71 Text en Copyright © 2010, Kodimuthali et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Preliminary Communication
Kodimuthali, Arumugam
Prasunamba, Padala Lakshmi
Pal, Manojit
Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring
title Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring
title_full Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring
title_fullStr Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring
title_full_unstemmed Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring
title_short Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring
title_sort synthesis of a novel analogue of dpp-4 inhibitor alogliptin: introduction of a spirocyclic moiety on the piperidine ring
topic Preliminary Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919267/
https://www.ncbi.nlm.nih.gov/pubmed/20703380
http://dx.doi.org/10.3762/bjoc.6.71
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AT palmanojit synthesisofanovelanalogueofdpp4inhibitoralogliptinintroductionofaspirocyclicmoietyonthepiperidinering

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