Cargando…

Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB

BACKGROUND: Reduced chemosensitivity of solid cancer cells represents a pivotal obstacle in clinical oncology. Hence, the molecular characterization of pathways regulating chemosensitivity is a central prerequisite to improve cancer therapy. The hypoxia-inducible factor HIF-1α has been linked to che...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rohwer, Nadine, Dame, Christof, Haugstetter, Anja, Wiedenmann, Bertram, Detjen, Katharina, Schmitt, Clemens A., Cramer, Thorsten
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919384/ https://www.ncbi.nlm.nih.gov/pubmed/20706634 http://dx.doi.org/10.1371/journal.pone.0012038

Ejemplares similares

Pomalidomide promotes chemosensitization of pancreatic cancer by inhibition of NF-κB
por: Shirai, Yoshihiro, et al.
Publicado: (2018)

Hypoxia Induced NF-κB
por: D’Ignazio, Laura, et al.
Publicado: (2016)

Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity
por: Walmsley, Sarah R., et al.
Publicado: (2005)

Aptamer-Mediated Codelivery of Doxorubicin and NF-κB Decoy Enhances Chemosensitivity of Pancreatic Tumor Cells
por: Porciani, David, et al.
Publicado: (2015)

Effects of hypoxia on human cancer cell line chemosensitivity
por: Strese, Sara, et al.
Publicado: (2013)

Anthocyanidins Inhibit Growth and Chemosensitize Triple-Negative Breast Cancer via the NF-κB Signaling Pathway
por: Aqil, Farrukh, et al.
Publicado: (2021)

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB
por: D’Ignazio, Laura, et al.
Publicado: (2017)

Chemosensitivity and p53; new tricks by an old dog
por: Lønning, Per E, et al.
Publicado: (2012)

Dexamethasone affects cell growth/apoptosis/chemosensitivity of colon cancer via glucocorticoid receptor α/NF-κB
por: He, Jianming, et al.
Publicado: (2017)

Fenofibrate potentiates chemosensitivity to human breast cancer cells by modulating apoptosis via AKT/NF-κB pathway
por: Sun, Jianguo, et al.
Publicado: (2019)

Inactivation of AKT/NF-κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin
por: Dukaew, Nahathai, et al.
Publicado: (2020)

The proline TP53 variant stimulates likely lymphangiogenesis in an orthotopic mouse model of pancreatic cancer
por: Otto, N, et al.
Publicado: (2012)

Regulation of hypoxia-inducible factor-1α by NF-κB
por: van Uden, Patrick, et al.
Publicado: (2008)

A Novel Function for the Tumor Suppressor p16(INK4a) : Induction of Anoikis via Upregulation of the α(5)β(1) Fibronectin Receptor
por: Plath, Thomas, et al.
Publicado: (2000)

Hypoxia. Regulation of NFκB signalling during inflammation: the role of hydroxylases
por: Oliver, Kathryn M, et al.
Publicado: (2009)

Hypoxia activates IKK–NF-κB and the immune response in Drosophila melanogaster
por: Bandarra, Daniel, et al.
Publicado: (2014)

Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling
por: Liu, Jiangbo, et al.
Publicado: (2014)

Ethyl P-Methoxycinnamate: An Active Anti-Metastasis Agent and Chemosensitizer Targeting NFκB from Kaempferia galanga for Melanoma Cells
por: Lallo, Subehan, et al.
Publicado: (2022)

Association of p53 and mitochondrial gene with chemosensitization by metformin in ovarian cancer
por: Wei, De-Hua, et al.
Publicado: (2017)

Expression of TP53 Isoforms p53β or p53γ Enhances Chemosensitivity in TP53(null) Cell Lines
por: Silden, Elisabeth, et al.
Publicado: (2013)

Epigenetic Upregulation of Metallothionein 2A by Diallyl Trisulfide Enhances Chemosensitivity of Human Gastric Cancer Cells to Docetaxel Through Attenuating NF-κB Activation
por: Pan, Yuanming, et al.
Publicado: (2016)

NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy
por: Grondona, Paula, et al.
Publicado: (2018)

Transcriptomic Deconvolution of Neuroendocrine Neoplasms Predicts Clinically Relevant Characteristics
por: Otto, Raik, et al.
Publicado: (2023)

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways
por: Ullah, Karim, et al.
Publicado: (2017)

AEG-1 is involved in hypoxia-induced autophagy and decreases chemosensitivity in T-cell lymphoma
por: Yan, Jiaqin, et al.
Publicado: (2018)

Chemosensitization in non-small cell lung cancer cells by IKK inhibitor occurs via NF-κB and mitochondrial cytochrome c cascade
por: Jin, Xianqing, et al.
Publicado: (2009)

Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression
por: Zhang, Shuaishuai, et al.
Publicado: (2016)

The Nexus between VEGF and NFκB Orchestrates a Hypoxia-Independent Neovasculogenesis
por: DeNiro, Michael, et al.
Publicado: (2013)

DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity
por: Cui, Danrui, et al.
Publicado: (2020)

Cooperative interactions between p53 and NFκB enhance cell plasticity
por: Bisio, Alessandra, et al.
Publicado: (2014)

MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3
por: Zhao, Na, et al.
Publicado: (2014)

Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway
por: Liu, Kaili, et al.
Publicado: (2020)

Tf-PEG-PLL-PLGA nanoparticles enhanced chemosensitivity for hypoxia-responsive tumor cells
por: Liu, Ping, et al.
Publicado: (2016)

Retraction: The Nexus between VEGF and NFκB Orchestrates a Hypoxia-Independent Neovasculogenesis
Publicado: (2019)

NF-κB p65 Attenuates Cardiomyocyte PGC-1α Expression in Hypoxia
por: Rabinovich-Nikitin, Inna, et al.
Publicado: (2022)

Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
por: Dreyfus, David H, et al.
Publicado: (2005)

Inhibition of protein FAK enhances 5-FU chemosensitivity to gastric carcinoma via p53 signaling pathways
por: Hou, Jingjing, et al.
Publicado: (2019)

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration
por: Jazvinšćak Jembrek, Maja, et al.
Publicado: (2021)

Activation of CDK4 by Tax chemosensitizes p53-mutant cells to DNA damage
por: Semmes, O John, et al.
Publicado: (2014)

Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer
por: Wang, Guosen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fovfdllk0dtlf2ep38i2aq81nv