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Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB

BACKGROUND: Reduced chemosensitivity of solid cancer cells represents a pivotal obstacle in clinical oncology. Hence, the molecular characterization of pathways regulating chemosensitivity is a central prerequisite to improve cancer therapy. The hypoxia-inducible factor HIF-1α has been linked to che...

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Detalles Bibliográficos
Autores principales:	Rohwer, Nadine, Dame, Christof, Haugstetter, Anja, Wiedenmann, Bertram, Detjen, Katharina, Schmitt, Clemens A., Cramer, Thorsten
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919384/ https://www.ncbi.nlm.nih.gov/pubmed/20706634 http://dx.doi.org/10.1371/journal.pone.0012038

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