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Insights in 17β-HSD1 Enzyme Kinetics and Ligand Binding by Dynamic Motion Investigation

BACKGROUND: Bisubstrate enzymes, such as 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), exist in solution as an ensemble of conformations. 17β-HSD1 catalyzes the last step of the biosynthesis of estradiol and, thus, it is a potentially attractive target for breast cancer treatment. METHODOLOGY/...

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Detalles Bibliográficos
Autores principales:	Negri, Matthias, Recanatini, Maurizio, Hartmann, Rolf W.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919385/ https://www.ncbi.nlm.nih.gov/pubmed/20706575 http://dx.doi.org/10.1371/journal.pone.0012026

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