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Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

Aberrant protein aggregation is a hallmark of many age-related diseases, yet little is known about whether proteins aggregate with age in a non-disease setting. Using a systematic proteomics approach, we identified several hundred proteins that become more insoluble with age in the multicellular org...

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Detalles Bibliográficos
Autores principales:	David, Della C., Ollikainen, Noah, Trinidad, Jonathan C., Cary, Michael P., Burlingame, Alma L., Kenyon, Cynthia
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919420/ https://www.ncbi.nlm.nih.gov/pubmed/20711477 http://dx.doi.org/10.1371/journal.pbio.1000450

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