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The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing
The use of short interfering RNAs (siRNA) in animals for target validation or as potential therapeutics is hindered by the short physical half-life when delivered as unencapsulated material and in turn the short active half-life of siRNAs in vivo. Here we demonstrate that the character of the two 3′...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919711/ https://www.ncbi.nlm.nih.gov/pubmed/20360048 http://dx.doi.org/10.1093/nar/gkq206 |