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A Simple Genetic Architecture Underlies Morphological Variation in Dogs

Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dog...

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Autores principales: Boyko, Adam R., Quignon, Pascale, Li, Lin, Schoenebeck, Jeffrey J., Degenhardt, Jeremiah D., Lohmueller, Kirk E., Zhao, Keyan, Brisbin, Abra, Parker, Heidi G., vonHoldt, Bridgett M., Cargill, Michele, Auton, Adam, Reynolds, Andy, Elkahloun, Abdel G., Castelhano, Marta, Mosher, Dana S., Sutter, Nathan B., Johnson, Gary S., Novembre, John, Hubisz, Melissa J., Siepel, Adam, Wayne, Robert K., Bustamante, Carlos D., Ostrander, Elaine A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919785/
https://www.ncbi.nlm.nih.gov/pubmed/20711490
http://dx.doi.org/10.1371/journal.pbio.1000451
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author Boyko, Adam R.
Quignon, Pascale
Li, Lin
Schoenebeck, Jeffrey J.
Degenhardt, Jeremiah D.
Lohmueller, Kirk E.
Zhao, Keyan
Brisbin, Abra
Parker, Heidi G.
vonHoldt, Bridgett M.
Cargill, Michele
Auton, Adam
Reynolds, Andy
Elkahloun, Abdel G.
Castelhano, Marta
Mosher, Dana S.
Sutter, Nathan B.
Johnson, Gary S.
Novembre, John
Hubisz, Melissa J.
Siepel, Adam
Wayne, Robert K.
Bustamante, Carlos D.
Ostrander, Elaine A.
author_facet Boyko, Adam R.
Quignon, Pascale
Li, Lin
Schoenebeck, Jeffrey J.
Degenhardt, Jeremiah D.
Lohmueller, Kirk E.
Zhao, Keyan
Brisbin, Abra
Parker, Heidi G.
vonHoldt, Bridgett M.
Cargill, Michele
Auton, Adam
Reynolds, Andy
Elkahloun, Abdel G.
Castelhano, Marta
Mosher, Dana S.
Sutter, Nathan B.
Johnson, Gary S.
Novembre, John
Hubisz, Melissa J.
Siepel, Adam
Wayne, Robert K.
Bustamante, Carlos D.
Ostrander, Elaine A.
author_sort Boyko, Adam R.
collection PubMed
description Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 single-nucleotide polymorphisms (SNPs). Coupling this genomic resource with external measurements from breed standards and individuals as well as skeletal measurements from museum specimens, we identify 51 regions of the dog genome associated with phenotypic variation among breeds in 57 traits. The complex traits include average breed body size and external body dimensions and cranial, dental, and long bone shape and size with and without allometric scaling. In contrast to the results from association mapping of quantitative traits in humans and domesticated plants, we find that across dog breeds, a small number of quantitative trait loci (≤3) explain the majority of phenotypic variation for most of the traits we studied. In addition, many genomic regions show signatures of recent selection, with most of the highly differentiated regions being associated with breed-defining traits such as body size, coat characteristics, and ear floppiness. Our results demonstrate the efficacy of mapping multiple traits in the domestic dog using a database of genotyped individuals and highlight the important role human-directed selection has played in altering the genetic architecture of key traits in this important species.
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spelling pubmed-29197852010-08-13 A Simple Genetic Architecture Underlies Morphological Variation in Dogs Boyko, Adam R. Quignon, Pascale Li, Lin Schoenebeck, Jeffrey J. Degenhardt, Jeremiah D. Lohmueller, Kirk E. Zhao, Keyan Brisbin, Abra Parker, Heidi G. vonHoldt, Bridgett M. Cargill, Michele Auton, Adam Reynolds, Andy Elkahloun, Abdel G. Castelhano, Marta Mosher, Dana S. Sutter, Nathan B. Johnson, Gary S. Novembre, John Hubisz, Melissa J. Siepel, Adam Wayne, Robert K. Bustamante, Carlos D. Ostrander, Elaine A. PLoS Biol Research Article Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 single-nucleotide polymorphisms (SNPs). Coupling this genomic resource with external measurements from breed standards and individuals as well as skeletal measurements from museum specimens, we identify 51 regions of the dog genome associated with phenotypic variation among breeds in 57 traits. The complex traits include average breed body size and external body dimensions and cranial, dental, and long bone shape and size with and without allometric scaling. In contrast to the results from association mapping of quantitative traits in humans and domesticated plants, we find that across dog breeds, a small number of quantitative trait loci (≤3) explain the majority of phenotypic variation for most of the traits we studied. In addition, many genomic regions show signatures of recent selection, with most of the highly differentiated regions being associated with breed-defining traits such as body size, coat characteristics, and ear floppiness. Our results demonstrate the efficacy of mapping multiple traits in the domestic dog using a database of genotyped individuals and highlight the important role human-directed selection has played in altering the genetic architecture of key traits in this important species. Public Library of Science 2010-08-10 /pmc/articles/PMC2919785/ /pubmed/20711490 http://dx.doi.org/10.1371/journal.pbio.1000451 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Boyko, Adam R.
Quignon, Pascale
Li, Lin
Schoenebeck, Jeffrey J.
Degenhardt, Jeremiah D.
Lohmueller, Kirk E.
Zhao, Keyan
Brisbin, Abra
Parker, Heidi G.
vonHoldt, Bridgett M.
Cargill, Michele
Auton, Adam
Reynolds, Andy
Elkahloun, Abdel G.
Castelhano, Marta
Mosher, Dana S.
Sutter, Nathan B.
Johnson, Gary S.
Novembre, John
Hubisz, Melissa J.
Siepel, Adam
Wayne, Robert K.
Bustamante, Carlos D.
Ostrander, Elaine A.
A Simple Genetic Architecture Underlies Morphological Variation in Dogs
title A Simple Genetic Architecture Underlies Morphological Variation in Dogs
title_full A Simple Genetic Architecture Underlies Morphological Variation in Dogs
title_fullStr A Simple Genetic Architecture Underlies Morphological Variation in Dogs
title_full_unstemmed A Simple Genetic Architecture Underlies Morphological Variation in Dogs
title_short A Simple Genetic Architecture Underlies Morphological Variation in Dogs
title_sort simple genetic architecture underlies morphological variation in dogs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919785/
https://www.ncbi.nlm.nih.gov/pubmed/20711490
http://dx.doi.org/10.1371/journal.pbio.1000451
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