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Diabetic Mastopathy: A Case Report and Literature Review
Diabetic mastopathy is a rare fibroinflammatory breast disease characterized by lymphocytic lobulitis, ductitis, and perivasculitis with stromal fibrosis. This lesion often presents as a discretely palpable uni- or bilateral mass in long-standing type I diabetes and other autoimmune diseases. We rep...
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Formato: | Texto |
Lenguaje: | English |
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S. Karger AG
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920008/ https://www.ncbi.nlm.nih.gov/pubmed/20740205 http://dx.doi.org/10.1159/000318641 |
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author | Neetu, G. Pathmanathan, R. Weng, Ngun Kok |
author_facet | Neetu, G. Pathmanathan, R. Weng, Ngun Kok |
author_sort | Neetu, G. |
collection | PubMed |
description | Diabetic mastopathy is a rare fibroinflammatory breast disease characterized by lymphocytic lobulitis, ductitis, and perivasculitis with stromal fibrosis. This lesion often presents as a discretely palpable uni- or bilateral mass in long-standing type I diabetes and other autoimmune diseases. We report a case of insulin-dependent diabetic mastopathy, which presented clinically as an indeterminate breast lump suspicious for malignancy. The patient is a 36-year-old woman who had type 1 insulin-dependent diabetes mellitus. Mammography and ultrasonography raised a suspicion of malignancy, and an excisional biopsy was performed. A previous biopsy had shown no evidence of malignancy. Histopathological examination now showed dense keloid-like stromal fibrosis with epithelioid-like and spindly myofibroblasts and a characteristic lymphocytic infiltration around blood vessels in and around lobules and ducts, features consistent with diabetic mastopathy. The literature is briefly reviewed. |
format | Text |
id | pubmed-2920008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-29200082010-08-25 Diabetic Mastopathy: A Case Report and Literature Review Neetu, G. Pathmanathan, R. Weng, Ngun Kok Case Rep Oncol Published: July 2010 Diabetic mastopathy is a rare fibroinflammatory breast disease characterized by lymphocytic lobulitis, ductitis, and perivasculitis with stromal fibrosis. This lesion often presents as a discretely palpable uni- or bilateral mass in long-standing type I diabetes and other autoimmune diseases. We report a case of insulin-dependent diabetic mastopathy, which presented clinically as an indeterminate breast lump suspicious for malignancy. The patient is a 36-year-old woman who had type 1 insulin-dependent diabetes mellitus. Mammography and ultrasonography raised a suspicion of malignancy, and an excisional biopsy was performed. A previous biopsy had shown no evidence of malignancy. Histopathological examination now showed dense keloid-like stromal fibrosis with epithelioid-like and spindly myofibroblasts and a characteristic lymphocytic infiltration around blood vessels in and around lobules and ducts, features consistent with diabetic mastopathy. The literature is briefly reviewed. S. Karger AG 2010-07-16 /pmc/articles/PMC2920008/ /pubmed/20740205 http://dx.doi.org/10.1159/000318641 Text en Copyright © 2010 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published: July 2010 Neetu, G. Pathmanathan, R. Weng, Ngun Kok Diabetic Mastopathy: A Case Report and Literature Review |
title | Diabetic Mastopathy: A Case Report and Literature Review |
title_full | Diabetic Mastopathy: A Case Report and Literature Review |
title_fullStr | Diabetic Mastopathy: A Case Report and Literature Review |
title_full_unstemmed | Diabetic Mastopathy: A Case Report and Literature Review |
title_short | Diabetic Mastopathy: A Case Report and Literature Review |
title_sort | diabetic mastopathy: a case report and literature review |
topic | Published: July 2010 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920008/ https://www.ncbi.nlm.nih.gov/pubmed/20740205 http://dx.doi.org/10.1159/000318641 |
work_keys_str_mv | AT neetug diabeticmastopathyacasereportandliteraturereview AT pathmanathanr diabeticmastopathyacasereportandliteraturereview AT wengngunkok diabeticmastopathyacasereportandliteraturereview |