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BMS-690514, a VEGFR and EGFR tyrosine kinase inhibitor, shows anti-tumoural activity on non-small-cell lung cancer xenografts and induces sequence-dependent synergistic effect with radiation

BACKGROUND: Non-small-cell lung cancer (NSCLC) is an aggressive disease in which vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) are implicated in tumour growth, tumour resistance to radiation and chemotherapy, and disease relapse. We have investigated the anti-tumoural e...

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Detalles Bibliográficos
Autores principales:	Loriot, Y, Mordant, P, Dorvault, N, De la motte Rouge, T, Bourhis, J, Soria, J-C, Deutsch, E
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920012/ https://www.ncbi.nlm.nih.gov/pubmed/20628392 http://dx.doi.org/10.1038/sj.bjc.6605748

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