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Microneedle-Based Transcutaneous Immunisation in Mice with N-Trimethyl Chitosan Adjuvanted Diphtheria Toxoid Formulations

PURPOSE: The purpose of this study was to gain insight into the delivery and immunogenicity of N-trimethyl chitosan (TMC) adjuvanted diphtheria toxoid (DT) formulations applied transcutaneously with microneedles. METHODS: Mice were vaccinated with DT-loaded TMC nanoparticles, a solution of TMC and D...

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Detalles Bibliográficos
Autores principales:	Bal, Suzanne M., Ding, Zhi, Kersten, Gideon F. A., Jiskoot, Wim, Bouwstra, Joke A.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer US 2010
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920068/ https://www.ncbi.nlm.nih.gov/pubmed/20559701 http://dx.doi.org/10.1007/s11095-010-0182-y

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