Cargando…
Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A
BACKGROUND: Within the past 3 years, four major evaluations of bisphenol A (BPA) safety have been undertaken. However, these assessments have arrived at quite different conclusions regarding the safety of BPA at current human exposure levels. OBJECTIVES: We compared the reasons provided by the Europ...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920081/ https://www.ncbi.nlm.nih.gov/pubmed/20444668 http://dx.doi.org/10.1289/ehp.0901717 |
_version_ | 1782185241090195456 |
---|---|
author | Vandenberg, Laura N. Chahoud, Ibrahim Padmanabhan, Vasantha Paumgartten, Francisco J.R. Schoenfelder, Gilbert |
author_facet | Vandenberg, Laura N. Chahoud, Ibrahim Padmanabhan, Vasantha Paumgartten, Francisco J.R. Schoenfelder, Gilbert |
author_sort | Vandenberg, Laura N. |
collection | PubMed |
description | BACKGROUND: Within the past 3 years, four major evaluations of bisphenol A (BPA) safety have been undertaken. However, these assessments have arrived at quite different conclusions regarding the safety of BPA at current human exposure levels. OBJECTIVES: We compared the reasons provided by the European Food Safety Authority (EFSA) BPA risk assessment panel for their conclusion that human exposures are negligible with the conclusions reached by the other panels, with all panels having the same body of literature at their disposal. DISCUSSION: The EFSA panel dismissed ≥ 80 biomonitoring studies that documented significant levels of BPA exposure in humans, including internal exposures to unconjugated BPA, on the basis that they did not match a model of BPA metabolism. Instead, the EFSA panel relied on two toxicokinetic studies—conducted in 15 adults administered BPA—to draw conclusions about exposure levels in the population, including exposures of neonates. CONCLUSIONS: As with all exposure assessments, models should be developed to explain actual data that are collected. In the case of BPA, samples from a large number of human subjects clearly indicate that humans are internally exposed to unconjugated BPA. The dismissal of these biomonitoring studies simply because their results do not conform to a model violates scientific principles. Expert panels should evaluate all data—including human biomonitoring studies—to make informed risk assessments. |
format | Text |
id | pubmed-2920081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-29200812010-09-08 Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A Vandenberg, Laura N. Chahoud, Ibrahim Padmanabhan, Vasantha Paumgartten, Francisco J.R. Schoenfelder, Gilbert Environ Health Perspect Commentary BACKGROUND: Within the past 3 years, four major evaluations of bisphenol A (BPA) safety have been undertaken. However, these assessments have arrived at quite different conclusions regarding the safety of BPA at current human exposure levels. OBJECTIVES: We compared the reasons provided by the European Food Safety Authority (EFSA) BPA risk assessment panel for their conclusion that human exposures are negligible with the conclusions reached by the other panels, with all panels having the same body of literature at their disposal. DISCUSSION: The EFSA panel dismissed ≥ 80 biomonitoring studies that documented significant levels of BPA exposure in humans, including internal exposures to unconjugated BPA, on the basis that they did not match a model of BPA metabolism. Instead, the EFSA panel relied on two toxicokinetic studies—conducted in 15 adults administered BPA—to draw conclusions about exposure levels in the population, including exposures of neonates. CONCLUSIONS: As with all exposure assessments, models should be developed to explain actual data that are collected. In the case of BPA, samples from a large number of human subjects clearly indicate that humans are internally exposed to unconjugated BPA. The dismissal of these biomonitoring studies simply because their results do not conform to a model violates scientific principles. Expert panels should evaluate all data—including human biomonitoring studies—to make informed risk assessments. National Institute of Environmental Health Sciences 2010-08 2010-05-05 /pmc/articles/PMC2920081/ /pubmed/20444668 http://dx.doi.org/10.1289/ehp.0901717 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Commentary Vandenberg, Laura N. Chahoud, Ibrahim Padmanabhan, Vasantha Paumgartten, Francisco J.R. Schoenfelder, Gilbert Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A |
title | Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A |
title_full | Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A |
title_fullStr | Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A |
title_full_unstemmed | Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A |
title_short | Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A |
title_sort | biomonitoring studies should be used by regulatory agencies to assess human exposure levels and safety of bisphenol a |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920081/ https://www.ncbi.nlm.nih.gov/pubmed/20444668 http://dx.doi.org/10.1289/ehp.0901717 |
work_keys_str_mv | AT vandenberglauran biomonitoringstudiesshouldbeusedbyregulatoryagenciestoassesshumanexposurelevelsandsafetyofbisphenola AT chahoudibrahim biomonitoringstudiesshouldbeusedbyregulatoryagenciestoassesshumanexposurelevelsandsafetyofbisphenola AT padmanabhanvasantha biomonitoringstudiesshouldbeusedbyregulatoryagenciestoassesshumanexposurelevelsandsafetyofbisphenola AT paumgarttenfranciscojr biomonitoringstudiesshouldbeusedbyregulatoryagenciestoassesshumanexposurelevelsandsafetyofbisphenola AT schoenfeldergilbert biomonitoringstudiesshouldbeusedbyregulatoryagenciestoassesshumanexposurelevelsandsafetyofbisphenola |