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Acaricidal Activity of Eugenol Based Compounds against Scabies Mites

BACKGOUND: Human scabies is a debilitating skin disease caused by the “itch mite” Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tole...

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Autores principales: Pasay, Cielo, Mounsey, Kate, Stevenson, Graeme, Davis, Rohan, Arlian, Larry, Morgan, Marjorie, Vyszenski-Moher, DiAnn, Andrews, Kathy, McCarthy, James
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920318/
https://www.ncbi.nlm.nih.gov/pubmed/20711455
http://dx.doi.org/10.1371/journal.pone.0012079
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author Pasay, Cielo
Mounsey, Kate
Stevenson, Graeme
Davis, Rohan
Arlian, Larry
Morgan, Marjorie
Vyszenski-Moher, DiAnn
Andrews, Kathy
McCarthy, James
author_facet Pasay, Cielo
Mounsey, Kate
Stevenson, Graeme
Davis, Rohan
Arlian, Larry
Morgan, Marjorie
Vyszenski-Moher, DiAnn
Andrews, Kathy
McCarthy, James
author_sort Pasay, Cielo
collection PubMed
description BACKGOUND: Human scabies is a debilitating skin disease caused by the “itch mite” Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tolerance in scabies endemic communities in Northern Australia have prompted efforts to better understand resistance mechanisms and to identify potential new acaricides. In this study, we screened three essential oils and four pure compounds based on eugenol for acaricidal properties. METHODOLOGY/PRINCIPAL FINDINGS: Contact bioassays were performed using live permethrin-sensitive S. scabiei var suis mites harvested from pigs and permethrin-resistant S. scabiei var canis mites harvested from rabbits. Results of bioassays showed that clove oil was highly toxic against scabies mites. Nutmeg oil had moderate toxicity and ylang ylang oil was the least toxic. Eugenol, a major component of clove oil and its analogues –acetyleugenol and isoeugenol, demonstrated levels of toxicity comparable to benzyl benzoate, the positive control acaricide, killing mites within an hour of contact. CONCLUSIONS: The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for future development of alternative topical acaricides to treat scabies.
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spelling pubmed-29203182010-08-13 Acaricidal Activity of Eugenol Based Compounds against Scabies Mites Pasay, Cielo Mounsey, Kate Stevenson, Graeme Davis, Rohan Arlian, Larry Morgan, Marjorie Vyszenski-Moher, DiAnn Andrews, Kathy McCarthy, James PLoS One Research Article BACKGOUND: Human scabies is a debilitating skin disease caused by the “itch mite” Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tolerance in scabies endemic communities in Northern Australia have prompted efforts to better understand resistance mechanisms and to identify potential new acaricides. In this study, we screened three essential oils and four pure compounds based on eugenol for acaricidal properties. METHODOLOGY/PRINCIPAL FINDINGS: Contact bioassays were performed using live permethrin-sensitive S. scabiei var suis mites harvested from pigs and permethrin-resistant S. scabiei var canis mites harvested from rabbits. Results of bioassays showed that clove oil was highly toxic against scabies mites. Nutmeg oil had moderate toxicity and ylang ylang oil was the least toxic. Eugenol, a major component of clove oil and its analogues –acetyleugenol and isoeugenol, demonstrated levels of toxicity comparable to benzyl benzoate, the positive control acaricide, killing mites within an hour of contact. CONCLUSIONS: The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for future development of alternative topical acaricides to treat scabies. Public Library of Science 2010-08-11 /pmc/articles/PMC2920318/ /pubmed/20711455 http://dx.doi.org/10.1371/journal.pone.0012079 Text en Pasay et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Pasay, Cielo
Mounsey, Kate
Stevenson, Graeme
Davis, Rohan
Arlian, Larry
Morgan, Marjorie
Vyszenski-Moher, DiAnn
Andrews, Kathy
McCarthy, James
Acaricidal Activity of Eugenol Based Compounds against Scabies Mites
title Acaricidal Activity of Eugenol Based Compounds against Scabies Mites
title_full Acaricidal Activity of Eugenol Based Compounds against Scabies Mites
title_fullStr Acaricidal Activity of Eugenol Based Compounds against Scabies Mites
title_full_unstemmed Acaricidal Activity of Eugenol Based Compounds against Scabies Mites
title_short Acaricidal Activity of Eugenol Based Compounds against Scabies Mites
title_sort acaricidal activity of eugenol based compounds against scabies mites
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920318/
https://www.ncbi.nlm.nih.gov/pubmed/20711455
http://dx.doi.org/10.1371/journal.pone.0012079
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