Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)

A new bioactive sterol glycoside, 3β-O-(3′,4′-di-O-acetyl-β-d-arabinopyranosyl) -25ξ-cholestane-3β,5α,6β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spec...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Chih-Yang, Hwang, Tsong-Long, Lin, Mei-Ru, Chen, Yung-Husan, Chang, Yu-Chia, Fang, Lee-Shing, Wang, Wei-Hsien, Wu, Yang-Chang, Sung, Ping-Jyun
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920540/
https://www.ncbi.nlm.nih.gov/pubmed/20714421
http://dx.doi.org/10.3390/md8072014
_version_ 1782185286679134208
author Liu, Chih-Yang
Hwang, Tsong-Long
Lin, Mei-Ru
Chen, Yung-Husan
Chang, Yu-Chia
Fang, Lee-Shing
Wang, Wei-Hsien
Wu, Yang-Chang
Sung, Ping-Jyun
author_facet Liu, Chih-Yang
Hwang, Tsong-Long
Lin, Mei-Ru
Chen, Yung-Husan
Chang, Yu-Chia
Fang, Lee-Shing
Wang, Wei-Hsien
Wu, Yang-Chang
Sung, Ping-Jyun
author_sort Liu, Chih-Yang
collection PubMed
description A new bioactive sterol glycoside, 3β-O-(3′,4′-di-O-acetyl-β-d-arabinopyranosyl) -25ξ-cholestane-3β,5α,6β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.
format Text
id pubmed-2920540
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Molecular Diversity Preservation International
record_format MEDLINE/PubMed
spelling pubmed-29205402010-08-16 Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae) Liu, Chih-Yang Hwang, Tsong-Long Lin, Mei-Ru Chen, Yung-Husan Chang, Yu-Chia Fang, Lee-Shing Wang, Wei-Hsien Wu, Yang-Chang Sung, Ping-Jyun Mar Drugs Article A new bioactive sterol glycoside, 3β-O-(3′,4′-di-O-acetyl-β-d-arabinopyranosyl) -25ξ-cholestane-3β,5α,6β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells. Molecular Diversity Preservation International 2010-06-29 /pmc/articles/PMC2920540/ /pubmed/20714421 http://dx.doi.org/10.3390/md8072014 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Liu, Chih-Yang
Hwang, Tsong-Long
Lin, Mei-Ru
Chen, Yung-Husan
Chang, Yu-Chia
Fang, Lee-Shing
Wang, Wei-Hsien
Wu, Yang-Chang
Sung, Ping-Jyun
Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)
title Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)
title_full Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)
title_fullStr Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)
title_full_unstemmed Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)
title_short Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)
title_sort carijoside a, a bioactive sterol glycoside from an octocoral carijoa sp. (clavulariidae)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920540/
https://www.ncbi.nlm.nih.gov/pubmed/20714421
http://dx.doi.org/10.3390/md8072014
work_keys_str_mv AT liuchihyang carijosideaabioactivesterolglycosidefromanoctocoralcarijoaspclavulariidae
AT hwangtsonglong carijosideaabioactivesterolglycosidefromanoctocoralcarijoaspclavulariidae
AT linmeiru carijosideaabioactivesterolglycosidefromanoctocoralcarijoaspclavulariidae
AT chenyunghusan carijosideaabioactivesterolglycosidefromanoctocoralcarijoaspclavulariidae
AT changyuchia carijosideaabioactivesterolglycosidefromanoctocoralcarijoaspclavulariidae
AT fangleeshing carijosideaabioactivesterolglycosidefromanoctocoralcarijoaspclavulariidae
AT wangweihsien carijosideaabioactivesterolglycosidefromanoctocoralcarijoaspclavulariidae
AT wuyangchang carijosideaabioactivesterolglycosidefromanoctocoralcarijoaspclavulariidae
AT sungpingjyun carijosideaabioactivesterolglycosidefromanoctocoralcarijoaspclavulariidae

Ejemplares similares