‘A mover and a shaker’: 53BP1 allows DNA doublestrand breaks a chance to dance and unite

The DNA damage response mediator protein, p53-binding protein 1 (53BP1), is dispensable for the repair of most DNA doublestrand breaks (DSBs) induced by ionising radiation. However, two recent studies have shown that 53BP1 is required for rejoining of distant DSB ends and that it promotes the moveme...

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Detalles Bibliográficos
Autores principales: Goodarzi, Aaron A, Jeggo, Penny A
Formato: Texto
Lenguaje:English
Publicado: Biology Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920668/
https://www.ncbi.nlm.nih.gov/pubmed/20948664
http://dx.doi.org/10.3410/B1-21
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author Goodarzi, Aaron A
Jeggo, Penny A
author_facet Goodarzi, Aaron A
Jeggo, Penny A
author_sort Goodarzi, Aaron A
collection PubMed
description The DNA damage response mediator protein, p53-binding protein 1 (53BP1), is dispensable for the repair of most DNA doublestrand breaks (DSBs) induced by ionising radiation. However, two recent studies have shown that 53BP1 is required for rejoining of distant DSB ends and that it promotes the movement of uncapped telomeres. These results are discussed in the light of recent findings, and a model for the role of 53BP1 in DSB rejoining is presented.
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spelling pubmed-29206682010-10-14 ‘A mover and a shaker’: 53BP1 allows DNA doublestrand breaks a chance to dance and unite Goodarzi, Aaron A Jeggo, Penny A F1000 Biol Rep Review Article The DNA damage response mediator protein, p53-binding protein 1 (53BP1), is dispensable for the repair of most DNA doublestrand breaks (DSBs) induced by ionising radiation. However, two recent studies have shown that 53BP1 is required for rejoining of distant DSB ends and that it promotes the movement of uncapped telomeres. These results are discussed in the light of recent findings, and a model for the role of 53BP1 in DSB rejoining is presented. Biology Reports Ltd 2009-03-17 /pmc/articles/PMC2920668/ /pubmed/20948664 http://dx.doi.org/10.3410/B1-21 Text en © 2009 Biology Reports Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Goodarzi, Aaron A
Jeggo, Penny A
‘A mover and a shaker’: 53BP1 allows DNA doublestrand breaks a chance to dance and unite
title ‘A mover and a shaker’: 53BP1 allows DNA doublestrand breaks a chance to dance and unite
title_full ‘A mover and a shaker’: 53BP1 allows DNA doublestrand breaks a chance to dance and unite
title_fullStr ‘A mover and a shaker’: 53BP1 allows DNA doublestrand breaks a chance to dance and unite
title_full_unstemmed ‘A mover and a shaker’: 53BP1 allows DNA doublestrand breaks a chance to dance and unite
title_short ‘A mover and a shaker’: 53BP1 allows DNA doublestrand breaks a chance to dance and unite
title_sort ‘a mover and a shaker’: 53bp1 allows dna doublestrand breaks a chance to dance and unite
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920668/
https://www.ncbi.nlm.nih.gov/pubmed/20948664
http://dx.doi.org/10.3410/B1-21
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