Mitochondria and apoptosis: a quick take on a long view

Fifteen years of apoptosis research have led to the widely accepted idea that the major form of programmed cell death in mammals proceeds via the mitochondria, and that mitochondrial control of apoptosis is regulated by a specialized family of proteins known as the Bcl-2 family. Here we will conside...

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Detalles Bibliográficos
Autores principales: Parsons, Melissa J, Green, Douglas R
Formato: Texto
Lenguaje:English
Publicado: Biology Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920673/
https://www.ncbi.nlm.nih.gov/pubmed/20948669
http://dx.doi.org/10.3410/B1-17
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author Parsons, Melissa J
Green, Douglas R
author_facet Parsons, Melissa J
Green, Douglas R
author_sort Parsons, Melissa J
collection PubMed
description Fifteen years of apoptosis research have led to the widely accepted idea that the major form of programmed cell death in mammals proceeds via the mitochondria, and that mitochondrial control of apoptosis is regulated by a specialized family of proteins known as the Bcl-2 family. Here we will consider some very recent data that has shed new insight into the regulation of these proteins and the impact of mitochondrial dynamics on mitochondrial outer membrane permeabilization (MOMP) and apoptosis.
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spelling pubmed-29206732010-10-14 Mitochondria and apoptosis: a quick take on a long view Parsons, Melissa J Green, Douglas R F1000 Biol Rep Review Article Fifteen years of apoptosis research have led to the widely accepted idea that the major form of programmed cell death in mammals proceeds via the mitochondria, and that mitochondrial control of apoptosis is regulated by a specialized family of proteins known as the Bcl-2 family. Here we will consider some very recent data that has shed new insight into the regulation of these proteins and the impact of mitochondrial dynamics on mitochondrial outer membrane permeabilization (MOMP) and apoptosis. Biology Reports Ltd 2009-02-24 /pmc/articles/PMC2920673/ /pubmed/20948669 http://dx.doi.org/10.3410/B1-17 Text en © 2009 Biology Reports Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Parsons, Melissa J
Green, Douglas R
Mitochondria and apoptosis: a quick take on a long view
title Mitochondria and apoptosis: a quick take on a long view
title_full Mitochondria and apoptosis: a quick take on a long view
title_fullStr Mitochondria and apoptosis: a quick take on a long view
title_full_unstemmed Mitochondria and apoptosis: a quick take on a long view
title_short Mitochondria and apoptosis: a quick take on a long view
title_sort mitochondria and apoptosis: a quick take on a long view
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920673/
https://www.ncbi.nlm.nih.gov/pubmed/20948669
http://dx.doi.org/10.3410/B1-17
work_keys_str_mv AT parsonsmelissaj mitochondriaandapoptosisaquicktakeonalongview
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