Septic shock: the changing Zeitgeist of management

Most interventions in critically unwell patients with septic shock are poorly supported by evidence, in part reflecting the difficulty of conducting trials in this heterogeneous group. Four important clinical trials in 2001-2 appeared to demonstrate mortality benefits associated with early goal-dire...

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Detalles Bibliográficos
Autores principales: Cheng, Allen C, Stephens, Dianne P
Formato: Texto
Lenguaje:English
Publicado: Medicine Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920691/
https://www.ncbi.nlm.nih.gov/pubmed/20948751
http://dx.doi.org/10.3410/M1-3
Descripción
Sumario:Most interventions in critically unwell patients with septic shock are poorly supported by evidence, in part reflecting the difficulty of conducting trials in this heterogeneous group. Four important clinical trials in 2001-2 appeared to demonstrate mortality benefits associated with early goal-directed resuscitation, intensive glycaemic control, physiological-dose steroid replacement and activated protein C. However, recent evidence has not confirmed the beneficial effect of these interventions.

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