Septic shock: the changing Zeitgeist of management

Most interventions in critically unwell patients with septic shock are poorly supported by evidence, in part reflecting the difficulty of conducting trials in this heterogeneous group. Four important clinical trials in 2001-2 appeared to demonstrate mortality benefits associated with early goal-dire...

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Detalles Bibliográficos
Autores principales: Cheng, Allen C, Stephens, Dianne P
Formato: Texto
Lenguaje:English
Publicado: Medicine Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920691/
https://www.ncbi.nlm.nih.gov/pubmed/20948751
http://dx.doi.org/10.3410/M1-3
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author Cheng, Allen C
Stephens, Dianne P
author_facet Cheng, Allen C
Stephens, Dianne P
author_sort Cheng, Allen C
collection PubMed
description Most interventions in critically unwell patients with septic shock are poorly supported by evidence, in part reflecting the difficulty of conducting trials in this heterogeneous group. Four important clinical trials in 2001-2 appeared to demonstrate mortality benefits associated with early goal-directed resuscitation, intensive glycaemic control, physiological-dose steroid replacement and activated protein C. However, recent evidence has not confirmed the beneficial effect of these interventions.
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spelling pubmed-29206912010-10-14 Septic shock: the changing Zeitgeist of management Cheng, Allen C Stephens, Dianne P F1000 Med Rep Review Article Most interventions in critically unwell patients with septic shock are poorly supported by evidence, in part reflecting the difficulty of conducting trials in this heterogeneous group. Four important clinical trials in 2001-2 appeared to demonstrate mortality benefits associated with early goal-directed resuscitation, intensive glycaemic control, physiological-dose steroid replacement and activated protein C. However, recent evidence has not confirmed the beneficial effect of these interventions. Medicine Reports Ltd 2009-01-21 /pmc/articles/PMC2920691/ /pubmed/20948751 http://dx.doi.org/10.3410/M1-3 Text en © 2009 Medicine Reports Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Cheng, Allen C
Stephens, Dianne P
Septic shock: the changing Zeitgeist of management
title Septic shock: the changing Zeitgeist of management
title_full Septic shock: the changing Zeitgeist of management
title_fullStr Septic shock: the changing Zeitgeist of management
title_full_unstemmed Septic shock: the changing Zeitgeist of management
title_short Septic shock: the changing Zeitgeist of management
title_sort septic shock: the changing zeitgeist of management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920691/
https://www.ncbi.nlm.nih.gov/pubmed/20948751
http://dx.doi.org/10.3410/M1-3
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