Telomere Disruption Results in Non-Random Formation of De Novo Dicentric Chromosomes Involving Acrocentric Human Chromosomes

Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly those in humans, can be quite stable, usually because one centromere is functi...

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Detalles Bibliográficos
Autores principales: Stimpson, Kaitlin M., Song, Ihn Young, Jauch, Anna, Holtgreve-Grez, Heidi, Hayden, Karen E., Bridger, Joanna M., Sullivan, Beth A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920838/
https://www.ncbi.nlm.nih.gov/pubmed/20711355
http://dx.doi.org/10.1371/journal.pgen.1001061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920838/
https://www.ncbi.nlm.nih.gov/pubmed/20711355
http://dx.doi.org/10.1371/journal.pgen.1001061

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