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Computational Analysis of Phosphopeptide Binding to the Polo-Box Domain of the Mitotic Kinase PLK1 Using Molecular Dynamics Simulation

The Polo-Like Kinase 1 (PLK1) acts as a central regulator of mitosis and is over-expressed in a wide range of human tumours where high levels of expression correlate with a poor prognosis. PLK1 comprises two structural elements, a kinase domain and a polo-box domain (PBD). The PBD binds phosphorylat...

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Detalles Bibliográficos
Autores principales:	Huggins, David J., McKenzie, Grahame J., Robinson, Daniel D., Narváez, Ana J., Hardwick, Bryn, Roberts-Thomson, Meredith, Venkitaraman, Ashok R., Grant, Guy H., Payne, Mike C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920843/ https://www.ncbi.nlm.nih.gov/pubmed/20711360 http://dx.doi.org/10.1371/journal.pcbi.1000880

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