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The Mycobacterium tuberculosis Proteasome Active Site Threonine Is Essential for Persistence Yet Dispensable for Replication and Resistance to Nitric Oxide

Previous work revealed that conditional depletion of the core proteasome subunits PrcB and PrcA impaired growth of Mycobacterium tuberculosis in vitro and in mouse lungs, caused hypersusceptibility to nitric oxide (NO) and impaired persistence of the bacilli during chronic mouse infections. Here, we...

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Detalles Bibliográficos
Autores principales:	Gandotra, Sheetal, Lebron, Maria B., Ehrt, Sabine
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920845/ https://www.ncbi.nlm.nih.gov/pubmed/20711362 http://dx.doi.org/10.1371/journal.ppat.1001040

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