Cargando…

Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits

Mitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and insulin-resistant individuals. Furthermore, inherited mutations in mitochondrial DNA can cause a rare form of diabetes. However, it is unclear whether mitochondrial dysfunction is a primary cause of the common...

Descripción completa

Detalles Bibliográficos
Autores principales:	Segrè, Ayellet V., Groop, Leif, Mootha, Vamsi K., Daly, Mark J., Altshuler, David
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920848/ https://www.ncbi.nlm.nih.gov/pubmed/20714348 http://dx.doi.org/10.1371/journal.pgen.1001058

Ejemplares similares

Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk
por: Segrè, Ayellet V., et al.
Publicado: (2015)

Gene Set of Nuclear-Encoded Mitochondrial Regulators Is Enriched for Common Inherited Variation in Obesity
por: Knoll, Nadja, et al.
Publicado: (2013)

Effects of Common Genetic Variants Associated With Type 2 Diabetes and Glycemic Traits on α- and β-Cell Function and Insulin Action in Humans
por: Jonsson, Anna, et al.
Publicado: (2013)

Hepatic NADH reductive stress underlies common variation in metabolic traits
por: Goodman, Russell P., et al.
Publicado: (2020)

Imeglimin‐mediated glycemic control in maternally inherited deafness and diabetes
por: Ishibashi, Ryoichi, et al.
Publicado: (2023)

Common genetic variants in ADCY5 and gestational glycemic traits
por: Lin, Rong, et al.
Publicado: (2020)

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins
por: Calvo, Sarah E., et al.
Publicado: (2016)

MCU encodes the pore conducting mitochondrial calcium currents
por: Chaudhuri, Dipayan, et al.
Publicado: (2013)

Mitochondrial membrane potential: a trait involved in organelle inheritance?
por: Milani, Liliana
Publicado: (2015)

Inheritance of mitochondrial DNA in humans: implications for rare and common diseases
por: Wei, W., et al.
Publicado: (2020)

Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics
por: Flicker, Daniel, et al.
Publicado: (2019)

Human genetic analyses of organelles highlight the nucleus in age-related trait heritability
por: Gupta, Rahul, et al.
Publicado: (2021)

Effects of maternal and fetal LEP common variants on maternal glycemic traits in pregnancy
por: Lin, Rong, et al.
Publicado: (2017)

Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes
por: Szendroedi, Julia, et al.
Publicado: (2009)

Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy
por: Lin, Rong, et al.
Publicado: (2017)

High-Resolution Mutation Mapping Reveals Parallel Experimental Evolution in Yeast
por: Segrè, Ayellet V, et al.
Publicado: (2006)

Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus
por: Powe, Camille E., et al.
Publicado: (2018)

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
por: Billings, Liana K., et al.
Publicado: (2012)

Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation
por: Gamazon, Eric R., et al.
Publicado: (2018)

Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression
por: Gohil, Vishal M., et al.
Publicado: (2010)

Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy
por: Chen, Hsiuchen, et al.
Publicado: (2015)

On the Effect of Asymmetrical Trait Inheritance on Models of Trait Evolution
por: Duchen, Pablo, et al.
Publicado: (2020)

Inherited common variants in mitochondrial DNA and invasive serous epithelial ovarian cancer risk
por: Earp, Madalene A, et al.
Publicado: (2013)

Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell
por: Mick, Eran, et al.
Publicado: (2020)

Mitochondrial DNA variation across 56,434 individuals in gnomAD
por: Laricchia, Kristen M., et al.
Publicado: (2022)

The inheritance of conformation traits in British Friesians
por: McClintock, AE, et al.
Publicado: (1980)

The inheritance of conformation traits in British Friesians
por: McClintock, AE, et al.
Publicado: (1980)

A Computational Screen for Regulators of Oxidative Phosphorylation Implicates SLIRP in Mitochondrial RNA Homeostasis
por: Baughman, Joshua M., et al.
Publicado: (2009)

Glycemic index and glycemic load of common fruit juices in Thailand
por: Visuthranukul, Chonnikant, et al.
Publicado: (2022)

Causal relationships between type 2 diabetes, glycemic traits and keratoconus
por: Zhu, Xueying, et al.
Publicado: (2023)

An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter
por: Ghosh, Sagnika, et al.
Publicado: (2020)

Structural insights into the Ca(2+)-dependent gating of the human mitochondrial calcium uniporter
por: Wang, Yan, et al.
Publicado: (2020)

Correction: A Computational Screen for Regulators of Oxidative Phosphorylation Implicates SLIRP in Mitochondrial RNA Homeostasis
por: Baughman, Joshua M., et al.
Publicado: (2010)

Inherited mitochondrial optic neuropathies
por: Yu-Wai-Man, P, et al.
Publicado: (2009)

Large-scale chemical dissection of mitochondrial function
por: Wagner, Bridget K., et al.
Publicado: (2008)

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA
por: Mok, Beverly Y., et al.
Publicado: (2022)

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition
por: Penna-Martinez, Marissa, et al.
Publicado: (2017)

The Trans-Ancestral Genomic Architecture of Glycemic Traits
por: Chen, Ji, et al.
Publicado: (2021)

Cryo-EM structure of the mitochondrial calcium uniporter
por: Nguyen, Nam X., et al.
Publicado: (2018)

Genetics of Type 2 Diabetes—Pitfalls and Possibilities
por: Prasad, Rashmi B., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_77u0hurejprc4kummba64lh2eu