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Quantification of myocardial perfusion using CMR with a radial data acquisition: comparison with a dual-bolus method

BACKGROUND: Quantitative estimates of myocardial perfusion generally require accurate measurement of the arterial input function (AIF). The saturation of signal intensity in the blood that occurs with most doses of contrast agent makes obtaining an accurate AIF challenging. This work seeks to evalua...

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Autores principales: Kim, Tae Ho, Pack, Nathan A, Chen, Liyong, DiBella, Edward VR
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920886/
https://www.ncbi.nlm.nih.gov/pubmed/20653961
http://dx.doi.org/10.1186/1532-429X-12-45
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author Kim, Tae Ho
Pack, Nathan A
Chen, Liyong
DiBella, Edward VR
author_facet Kim, Tae Ho
Pack, Nathan A
Chen, Liyong
DiBella, Edward VR
author_sort Kim, Tae Ho
collection PubMed
description BACKGROUND: Quantitative estimates of myocardial perfusion generally require accurate measurement of the arterial input function (AIF). The saturation of signal intensity in the blood that occurs with most doses of contrast agent makes obtaining an accurate AIF challenging. This work seeks to evaluate the performance of a method that uses a radial k-space perfusion sequence and multiple saturation recovery times (SRT) to quantify myocardial perfusion with cardiovascular magnetic resonance (CMR). METHODS: Perfusion CMR was performed at 3 Tesla with a saturation recovery radial turboFLASH sequence with 72 rays. Fourteen subjects were given a low dose (0.004 mmol/kg) of dilute (1/5 concentration) contrast agent (Gd-BOPTA) and then a higher non-dilute dose of the same volume (0.02 mmol/kg). AIFs were calculated from the blood signal in three sub-images with differing effective saturation recovery times. The full and sub-images were reconstructed iteratively with a total variation constraint. The images from the full 72 ray data were processed to obtain six tissue enhancement curves in two slices of the left ventricle in each subject. A 2-compartment model was used to determine absolute flows RESULTS: The proposed multi-SRT method resulted in AIFs that were similar to those obtained with the dual-bolus method. Myocardial blood flow (MBF) estimates from the dual-bolus and the multi-SRT methods were related by MBF(multi-SRT )= 0.85MBF(dual-bolus )+ 0.18 (r = 0.91). CONCLUSIONS: The multi-SRT method, which uses a radial k-space perfusion sequence, can be used to obtain an accurate AIF and thus quantify myocardial perfusion for doses of contrast agent that result in a relatively saturated AIF.
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spelling pubmed-29208862010-08-13 Quantification of myocardial perfusion using CMR with a radial data acquisition: comparison with a dual-bolus method Kim, Tae Ho Pack, Nathan A Chen, Liyong DiBella, Edward VR J Cardiovasc Magn Reson Research BACKGROUND: Quantitative estimates of myocardial perfusion generally require accurate measurement of the arterial input function (AIF). The saturation of signal intensity in the blood that occurs with most doses of contrast agent makes obtaining an accurate AIF challenging. This work seeks to evaluate the performance of a method that uses a radial k-space perfusion sequence and multiple saturation recovery times (SRT) to quantify myocardial perfusion with cardiovascular magnetic resonance (CMR). METHODS: Perfusion CMR was performed at 3 Tesla with a saturation recovery radial turboFLASH sequence with 72 rays. Fourteen subjects were given a low dose (0.004 mmol/kg) of dilute (1/5 concentration) contrast agent (Gd-BOPTA) and then a higher non-dilute dose of the same volume (0.02 mmol/kg). AIFs were calculated from the blood signal in three sub-images with differing effective saturation recovery times. The full and sub-images were reconstructed iteratively with a total variation constraint. The images from the full 72 ray data were processed to obtain six tissue enhancement curves in two slices of the left ventricle in each subject. A 2-compartment model was used to determine absolute flows RESULTS: The proposed multi-SRT method resulted in AIFs that were similar to those obtained with the dual-bolus method. Myocardial blood flow (MBF) estimates from the dual-bolus and the multi-SRT methods were related by MBF(multi-SRT )= 0.85MBF(dual-bolus )+ 0.18 (r = 0.91). CONCLUSIONS: The multi-SRT method, which uses a radial k-space perfusion sequence, can be used to obtain an accurate AIF and thus quantify myocardial perfusion for doses of contrast agent that result in a relatively saturated AIF. BioMed Central 2010-07-23 /pmc/articles/PMC2920886/ /pubmed/20653961 http://dx.doi.org/10.1186/1532-429X-12-45 Text en Copyright ©2010 Kim et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Kim, Tae Ho
Pack, Nathan A
Chen, Liyong
DiBella, Edward VR
Quantification of myocardial perfusion using CMR with a radial data acquisition: comparison with a dual-bolus method
title Quantification of myocardial perfusion using CMR with a radial data acquisition: comparison with a dual-bolus method
title_full Quantification of myocardial perfusion using CMR with a radial data acquisition: comparison with a dual-bolus method
title_fullStr Quantification of myocardial perfusion using CMR with a radial data acquisition: comparison with a dual-bolus method
title_full_unstemmed Quantification of myocardial perfusion using CMR with a radial data acquisition: comparison with a dual-bolus method
title_short Quantification of myocardial perfusion using CMR with a radial data acquisition: comparison with a dual-bolus method
title_sort quantification of myocardial perfusion using cmr with a radial data acquisition: comparison with a dual-bolus method
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920886/
https://www.ncbi.nlm.nih.gov/pubmed/20653961
http://dx.doi.org/10.1186/1532-429X-12-45
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