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Imminent brain death: point of departure for potential heart-beating organ donor recognition

PURPOSE: There is, in European countries that conduct medical chart review of intensive care unit (ICU) deaths, no consensus on uniform criteria for defining a potential organ donor. Although the term is increasingly being used in recent literature, it is seldom defined in detail. We searched for cr...

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Autores principales: de Groot, Yorick J., Jansen, Nichon E., Bakker, Jan, Kuiper, Michael A., Aerdts, Stan, Maas, Andrew I. R., Wijdicks, Eelco F. M., van Leiden, Hendrik A., Hoitsma, Andries J., Kremer, Berry (H.P.H.), Kompanje, Erwin J. O.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921050/
https://www.ncbi.nlm.nih.gov/pubmed/20232039
http://dx.doi.org/10.1007/s00134-010-1848-y
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author de Groot, Yorick J.
Jansen, Nichon E.
Bakker, Jan
Kuiper, Michael A.
Aerdts, Stan
Maas, Andrew I. R.
Wijdicks, Eelco F. M.
van Leiden, Hendrik A.
Hoitsma, Andries J.
Kremer, Berry (H.P.H.)
Kompanje, Erwin J. O.
author_facet de Groot, Yorick J.
Jansen, Nichon E.
Bakker, Jan
Kuiper, Michael A.
Aerdts, Stan
Maas, Andrew I. R.
Wijdicks, Eelco F. M.
van Leiden, Hendrik A.
Hoitsma, Andries J.
Kremer, Berry (H.P.H.)
Kompanje, Erwin J. O.
author_sort de Groot, Yorick J.
collection PubMed
description PURPOSE: There is, in European countries that conduct medical chart review of intensive care unit (ICU) deaths, no consensus on uniform criteria for defining a potential organ donor. Although the term is increasingly being used in recent literature, it is seldom defined in detail. We searched for criteria for determination of imminent brain death, which can be seen as a precursor for organ donation. METHODS: We organized meetings with representatives from the field of clinical neurology, neurotraumatology, intensive care medicine, transplantation medicine, clinical intensive care ethics, and organ procurement management. During these meetings, all possible criteria were discussed to identify a patient with a reasonable probability to become brain dead (imminent brain death). We focused on the practical usefulness of two validated coma scales (Glasgow Coma Scale and the FOUR Score), brain stem reflexes and respiration to define imminent brain death. Further we discussed criteria to determine irreversibility and futility in acute neurological conditions. RESULTS: A patient who fulfills the definition of imminent brain death is a mechanically ventilated deeply comatose patient, admitted to an ICU, with irreversible catastrophic brain damage of known origin. A condition of imminent brain death requires either a Glasgow Coma Score of 3 and the progressive absence of at least three out of six brain stem reflexes or a FOUR score of E(0)M(0)B(0)R(0). CONCLUSION: The definition of imminent brain death can be used as a point of departure for potential heart-beating organ donor recognition on the intensive care unit or retrospective medical chart analysis.
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spelling pubmed-29210502010-08-20 Imminent brain death: point of departure for potential heart-beating organ donor recognition de Groot, Yorick J. Jansen, Nichon E. Bakker, Jan Kuiper, Michael A. Aerdts, Stan Maas, Andrew I. R. Wijdicks, Eelco F. M. van Leiden, Hendrik A. Hoitsma, Andries J. Kremer, Berry (H.P.H.) Kompanje, Erwin J. O. Intensive Care Med Original PURPOSE: There is, in European countries that conduct medical chart review of intensive care unit (ICU) deaths, no consensus on uniform criteria for defining a potential organ donor. Although the term is increasingly being used in recent literature, it is seldom defined in detail. We searched for criteria for determination of imminent brain death, which can be seen as a precursor for organ donation. METHODS: We organized meetings with representatives from the field of clinical neurology, neurotraumatology, intensive care medicine, transplantation medicine, clinical intensive care ethics, and organ procurement management. During these meetings, all possible criteria were discussed to identify a patient with a reasonable probability to become brain dead (imminent brain death). We focused on the practical usefulness of two validated coma scales (Glasgow Coma Scale and the FOUR Score), brain stem reflexes and respiration to define imminent brain death. Further we discussed criteria to determine irreversibility and futility in acute neurological conditions. RESULTS: A patient who fulfills the definition of imminent brain death is a mechanically ventilated deeply comatose patient, admitted to an ICU, with irreversible catastrophic brain damage of known origin. A condition of imminent brain death requires either a Glasgow Coma Score of 3 and the progressive absence of at least three out of six brain stem reflexes or a FOUR score of E(0)M(0)B(0)R(0). CONCLUSION: The definition of imminent brain death can be used as a point of departure for potential heart-beating organ donor recognition on the intensive care unit or retrospective medical chart analysis. Springer-Verlag 2010-03-16 2010 /pmc/articles/PMC2921050/ /pubmed/20232039 http://dx.doi.org/10.1007/s00134-010-1848-y Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original
de Groot, Yorick J.
Jansen, Nichon E.
Bakker, Jan
Kuiper, Michael A.
Aerdts, Stan
Maas, Andrew I. R.
Wijdicks, Eelco F. M.
van Leiden, Hendrik A.
Hoitsma, Andries J.
Kremer, Berry (H.P.H.)
Kompanje, Erwin J. O.
Imminent brain death: point of departure for potential heart-beating organ donor recognition
title Imminent brain death: point of departure for potential heart-beating organ donor recognition
title_full Imminent brain death: point of departure for potential heart-beating organ donor recognition
title_fullStr Imminent brain death: point of departure for potential heart-beating organ donor recognition
title_full_unstemmed Imminent brain death: point of departure for potential heart-beating organ donor recognition
title_short Imminent brain death: point of departure for potential heart-beating organ donor recognition
title_sort imminent brain death: point of departure for potential heart-beating organ donor recognition
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921050/
https://www.ncbi.nlm.nih.gov/pubmed/20232039
http://dx.doi.org/10.1007/s00134-010-1848-y
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