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Optimization of total protein and activity assays for the detection of MMP-12 in induced human sputum
BACKGROUND: Proteolysis of matrix components, in particular elastin, is a major contributing factor to the development of lung diseases such as emphysema and chronic obstructive pulmonary disease (COPD). MMP-12 (macrophage elastase) is a protease known to be involved in the progression of lung disea...
Autores principales: | LaPan, Peter, Brady, Jeff, Grierson, Christal, Fleming, Margaret, Miller, Doug, Sypek, Joe, Fu, Bin |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921351/ https://www.ncbi.nlm.nih.gov/pubmed/20678199 http://dx.doi.org/10.1186/1471-2466-10-40 |
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