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Endoplasmic reticulum stress response in an INS-1 pancreatic β-cell line with inducible expression of a folding-deficient proinsulin

BACKGROUND: Cells respond to endoplasmic reticulum stress (ER) stress by activating the unfolded protein response. To study the ER stress response in pancreatic β-cells we developed a model system that allows for pathophysiological ER stress based on the Akita mouse. This mouse strain expresses a mu...

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Detalles Bibliográficos
Autores principales:	Hartley, Taila, Siva, Madura, Lai, Elida, Teodoro, Tracy, Zhang, Liling, Volchuk, Allen
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921384/ https://www.ncbi.nlm.nih.gov/pubmed/20659334 http://dx.doi.org/10.1186/1471-2121-11-59

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