Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

BACKGROUND: Transient stimulation of the innate immune system by an intraperitoneal injection of lipopolysaccharide (LPS) activates peripheral and central expression of the tryptophan degrading enzyme indoleamine 2,3 dioxygenase (IDO) which mediates depressive-like behavior. It is unknown whether di...

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Detalles Bibliográficos
Autores principales: Fu, Xin, Zunich, Samantha M, O'Connor, Jason C, Kavelaars, Annemieke, Dantzer, Robert, Kelley, Keith W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921406/
https://www.ncbi.nlm.nih.gov/pubmed/20678226
http://dx.doi.org/10.1186/1742-2094-7-43

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