APOBEC3 proteins mediate the clearance of foreign DNA from human cells

Bacteria evolved restriction endonucleases to prevent interspecies DNA transmission and bacteriophage infection. Here, we show that human cells possess an analogous mechanism. APOBEC3A is induced by interferon following DNA detection, and it deaminates foreign double-stranded DNA cytidines to uridin...

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Detalles Bibliográficos
Autores principales: Stenglein, Mark D., Burns, Michael B., Li, Ming, Lengyel, Joy, Harris, Reuben S.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921484/
https://www.ncbi.nlm.nih.gov/pubmed/20062055
http://dx.doi.org/10.1038/nsmb.1744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921484/
https://www.ncbi.nlm.nih.gov/pubmed/20062055
http://dx.doi.org/10.1038/nsmb.1744

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