To automate or not to automate: this is the question

New protocols and instrumentation significantly boost the outcome of structural biology, which has resulted in significant growth in the number of deposited Protein Data Bank structures. However, even an enormous increase of the productivity of a single step of the structure determination process ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Cymborowski, M., Klimecka, M., Chruszcz, M., Zimmerman, M. D., Shumilin, I. A., Borek, D., Lazarski, K., Joachimiak, A., Otwinowski, Z., Anderson, W., Minor, W.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921494/
https://www.ncbi.nlm.nih.gov/pubmed/20526815
http://dx.doi.org/10.1007/s10969-010-9092-9
_version_ 1782185394336432128
author Cymborowski, M.
Klimecka, M.
Chruszcz, M.
Zimmerman, M. D.
Shumilin, I. A.
Borek, D.
Lazarski, K.
Joachimiak, A.
Otwinowski, Z.
Anderson, W.
Minor, W.
author_facet Cymborowski, M.
Klimecka, M.
Chruszcz, M.
Zimmerman, M. D.
Shumilin, I. A.
Borek, D.
Lazarski, K.
Joachimiak, A.
Otwinowski, Z.
Anderson, W.
Minor, W.
author_sort Cymborowski, M.
collection PubMed
description New protocols and instrumentation significantly boost the outcome of structural biology, which has resulted in significant growth in the number of deposited Protein Data Bank structures. However, even an enormous increase of the productivity of a single step of the structure determination process may not significantly shorten the time between clone and deposition or publication. For example, in a medium size laboratory equipped with the LabDB and HKL-3000 systems, we show that automation of some (and integration of all) steps of the X-ray structure determination pathway is critical for laboratory productivity. Moreover, we show that the lag period after which the impact of a technology change is observed is longer than expected.
format Text
id pubmed-2921494
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-29214942010-08-20 To automate or not to automate: this is the question Cymborowski, M. Klimecka, M. Chruszcz, M. Zimmerman, M. D. Shumilin, I. A. Borek, D. Lazarski, K. Joachimiak, A. Otwinowski, Z. Anderson, W. Minor, W. J Struct Funct Genomics Article New protocols and instrumentation significantly boost the outcome of structural biology, which has resulted in significant growth in the number of deposited Protein Data Bank structures. However, even an enormous increase of the productivity of a single step of the structure determination process may not significantly shorten the time between clone and deposition or publication. For example, in a medium size laboratory equipped with the LabDB and HKL-3000 systems, we show that automation of some (and integration of all) steps of the X-ray structure determination pathway is critical for laboratory productivity. Moreover, we show that the lag period after which the impact of a technology change is observed is longer than expected. Springer Netherlands 2010-06-06 2010 /pmc/articles/PMC2921494/ /pubmed/20526815 http://dx.doi.org/10.1007/s10969-010-9092-9 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Cymborowski, M.
Klimecka, M.
Chruszcz, M.
Zimmerman, M. D.
Shumilin, I. A.
Borek, D.
Lazarski, K.
Joachimiak, A.
Otwinowski, Z.
Anderson, W.
Minor, W.
To automate or not to automate: this is the question
title To automate or not to automate: this is the question
title_full To automate or not to automate: this is the question
title_fullStr To automate or not to automate: this is the question
title_full_unstemmed To automate or not to automate: this is the question
title_short To automate or not to automate: this is the question
title_sort to automate or not to automate: this is the question
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921494/
https://www.ncbi.nlm.nih.gov/pubmed/20526815
http://dx.doi.org/10.1007/s10969-010-9092-9
work_keys_str_mv AT cymborowskim toautomateornottoautomatethisisthequestion
AT klimeckam toautomateornottoautomatethisisthequestion
AT chruszczm toautomateornottoautomatethisisthequestion
AT zimmermanmd toautomateornottoautomatethisisthequestion
AT shumilinia toautomateornottoautomatethisisthequestion
AT borekd toautomateornottoautomatethisisthequestion
AT lazarskik toautomateornottoautomatethisisthequestion
AT joachimiaka toautomateornottoautomatethisisthequestion
AT otwinowskiz toautomateornottoautomatethisisthequestion
AT andersonw toautomateornottoautomatethisisthequestion
AT minorw toautomateornottoautomatethisisthequestion

Ejemplares similares