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Loss of PHLPP expression in colon cancer: Role in proliferation and tumorigenesis

PHLPP (PH domain Leucine-rich-repeats Protein Phosphatase) represents a family of novel Ser/Thr protein phosphatases. Two highly related isoforms in this family, PHLPP1 and PHLPP2, have been identified to serve as negative regulators of Akt and protein kinase C (PKC) by dephosphorylating the kinases...

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Detalles Bibliográficos
Autores principales:	Liu, Jianyu, Weiss, Heidi L., Rychahou, Piotr, Jackson, Lindsey N., Evers, B. Mark, Gao, Tianyan
Formato:	Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921630/ https://www.ncbi.nlm.nih.gov/pubmed/19079341 http://dx.doi.org/10.1038/onc.2008.450

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