Mutagenic conformation of 8-oxo-7,8-dihydro-2′-dGTP in the confines of a DNA polymerase active site

The major product of oxidative base damage is 8-oxo-7,8-dihydro-2′-deoxyguanine (8odG). The coding potential of this lesion is modulated by its glycosidic torsion angle that controls whether its Watson-Crick or Hoogsteen edge is utilized for base pairing. The 2.0 Å structure of DNA polymerase (pol)...

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Detalles Bibliográficos
Autores principales: Batra, Vinod K., Beard, William A., Hou, Esther W., Pedersen, Lars C., Prasad, Rajendra, Wilson, Samuel H.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921931/
https://www.ncbi.nlm.nih.gov/pubmed/20526335
http://dx.doi.org/10.1038/nsmb.1852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921931/
https://www.ncbi.nlm.nih.gov/pubmed/20526335
http://dx.doi.org/10.1038/nsmb.1852

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