Kinesin-14: the roots of reversal

Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes a dock-undock cycle, like that of plus-end-dir...

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Detalles Bibliográficos
Autor principal: Cross, Robert A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922096/
https://www.ncbi.nlm.nih.gov/pubmed/20731883
http://dx.doi.org/10.1186/1741-7007-8-107
Descripción
Sumario:Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes a dock-undock cycle, like that of plus-end-directed kinesins. See research article: http://www.biomedcentral.com/1472-6807/10/19

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