Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression

BACKGROUND: p53 is the most studied tumor suppressor and its overexpression may or may not cause cell death depending upon the genetic background of the cells. p53 is degraded by human papillomavirus (HPV) E6 protein in cervical carcinoma. Several stress activated kinases are known to phosphorylate...

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Detalles Bibliográficos
Autores principales: Ajay, Amrendra K, Upadhyay, Ankur K, Singh, Sandeep, Vijayakumar, Maleppillil V, Kumari, Ratna, Pandey, Vimal, Boppana, Ramanamurthy, Bhat, Manoj K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922192/
https://www.ncbi.nlm.nih.gov/pubmed/20673369
http://dx.doi.org/10.1186/1476-4598-9-204

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