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Successful thrombolysis of a thrombosed prosthetic mitral valve using a synthetic tissue plasminogen activator: a case report

INTRODUCTION: Prosthetic valve thrombosis is a rare but life-threatening condition that requires careful evaluation and prompt treatment. While surgical intervention remains the gold standard, thrombolytic therapy is now emerging as a potential substitute. Various thrombolytic treatments including s...

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Autores principales: Al-Sarraf, Nael, Al-Shammari, Fahad, Al-Fadhli, Jamal, Al-Shawaf, Emad
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922301/
https://www.ncbi.nlm.nih.gov/pubmed/20682069
http://dx.doi.org/10.1186/1752-1947-4-241
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author Al-Sarraf, Nael
Al-Shammari, Fahad
Al-Fadhli, Jamal
Al-Shawaf, Emad
author_facet Al-Sarraf, Nael
Al-Shammari, Fahad
Al-Fadhli, Jamal
Al-Shawaf, Emad
author_sort Al-Sarraf, Nael
collection PubMed
description INTRODUCTION: Prosthetic valve thrombosis is a rare but life-threatening condition that requires careful evaluation and prompt treatment. While surgical intervention remains the gold standard, thrombolytic therapy is now emerging as a potential substitute. Various thrombolytic treatments including streptokinase, urokinase and recombinant tissue plasminogen activators have been reported with variable success rates. However, the data on the use of tenecteplase (a synthetic tissue plasminogen activator) is limited. CASE PRESENTATION: A 44-year-old Middle Eastern man with a previously implanted prosthetic mitral valve presented with exertional dyspnea and orthopnea. Investigations revealed a thrombosed prosthetic mitral valve. Successful thrombolysis was achieved using tenecteplase which lead to the complete restoration of valve function with no risk to the patient. CONCLUSION: Prosthetic valve thrombosis is a rare but life threatening condition, the diagnosis of which requires a high index of suspicion. Tenecteplase can be used successfully in the management of such cases. It has proved to be useful with no extra risk to the patient.
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spelling pubmed-29223012010-08-17 Successful thrombolysis of a thrombosed prosthetic mitral valve using a synthetic tissue plasminogen activator: a case report Al-Sarraf, Nael Al-Shammari, Fahad Al-Fadhli, Jamal Al-Shawaf, Emad J Med Case Reports Case Report INTRODUCTION: Prosthetic valve thrombosis is a rare but life-threatening condition that requires careful evaluation and prompt treatment. While surgical intervention remains the gold standard, thrombolytic therapy is now emerging as a potential substitute. Various thrombolytic treatments including streptokinase, urokinase and recombinant tissue plasminogen activators have been reported with variable success rates. However, the data on the use of tenecteplase (a synthetic tissue plasminogen activator) is limited. CASE PRESENTATION: A 44-year-old Middle Eastern man with a previously implanted prosthetic mitral valve presented with exertional dyspnea and orthopnea. Investigations revealed a thrombosed prosthetic mitral valve. Successful thrombolysis was achieved using tenecteplase which lead to the complete restoration of valve function with no risk to the patient. CONCLUSION: Prosthetic valve thrombosis is a rare but life threatening condition, the diagnosis of which requires a high index of suspicion. Tenecteplase can be used successfully in the management of such cases. It has proved to be useful with no extra risk to the patient. BioMed Central 2010-08-03 /pmc/articles/PMC2922301/ /pubmed/20682069 http://dx.doi.org/10.1186/1752-1947-4-241 Text en Copyright ©2010 Al-Sarraf et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Al-Sarraf, Nael
Al-Shammari, Fahad
Al-Fadhli, Jamal
Al-Shawaf, Emad
Successful thrombolysis of a thrombosed prosthetic mitral valve using a synthetic tissue plasminogen activator: a case report
title Successful thrombolysis of a thrombosed prosthetic mitral valve using a synthetic tissue plasminogen activator: a case report
title_full Successful thrombolysis of a thrombosed prosthetic mitral valve using a synthetic tissue plasminogen activator: a case report
title_fullStr Successful thrombolysis of a thrombosed prosthetic mitral valve using a synthetic tissue plasminogen activator: a case report
title_full_unstemmed Successful thrombolysis of a thrombosed prosthetic mitral valve using a synthetic tissue plasminogen activator: a case report
title_short Successful thrombolysis of a thrombosed prosthetic mitral valve using a synthetic tissue plasminogen activator: a case report
title_sort successful thrombolysis of a thrombosed prosthetic mitral valve using a synthetic tissue plasminogen activator: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922301/
https://www.ncbi.nlm.nih.gov/pubmed/20682069
http://dx.doi.org/10.1186/1752-1947-4-241
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