Overexpression of Inosine 5′-Monophosphate Dehydrogenase Type II Mediates Chemoresistance to Human Osteosarcoma Cells

BACKGROUND: Chemoresistance is the principal reason for poor survival and disease recurrence in osteosarcoma patients. Inosine 5′-monophosphate dehydrogenase type II (IMPDH2) encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis and has been linked to cell growth, different...

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Detalles Bibliográficos
Autores principales: Fellenberg, Jörg, Kunz, Pierre, Sähr, Heiner, Depeweg, Daniela
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922339/
https://www.ncbi.nlm.nih.gov/pubmed/20808934
http://dx.doi.org/10.1371/journal.pone.0012179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922339/
https://www.ncbi.nlm.nih.gov/pubmed/20808934
http://dx.doi.org/10.1371/journal.pone.0012179

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