Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIP(L)

Cellular FADD-like interleukin-1β–converting enzyme inhibitory proteins (c-FLIPs; isoforms c-FLIP long [c-FLIP(L)], c-FLIP short [c-FLIP(S)], and c-FLIP Raji [c-FLIP(R)]) regulate caspase-8 activation and death receptor (DR)–induced apoptosis. In this study, using a combination of mathematical model...

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Detalles Bibliográficos
Autores principales: Fricker, Nicolai, Beaudouin, Joel, Richter, Petra, Eils, Roland, Krammer, Peter H., Lavrik, Inna N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922645/
https://www.ncbi.nlm.nih.gov/pubmed/20696707
http://dx.doi.org/10.1083/jcb.201002060

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