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Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings
Gastroblastoma is a rare gastric epitheliomesenchymal biphasic tumour composed of spindle and epithelial cells, reported by Miettinen et al in a series of three cases in 2009. All those cases arose in stomachs of young adults. Neither the epithelial nor the mesenchymal component displayed sufficient...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BMJ Group
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922722/ https://www.ncbi.nlm.nih.gov/pubmed/20203230 http://dx.doi.org/10.1136/jcp.2009.074104 |
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author | Shin, Dong Hoon Lee, Jung Hee Kang, Hyun Jeong Choi, Kyung Un Kim, Jee Yeon Park, Do Youn Lee, Chang Hun Sol, Mee Young Park, Jae Hong Kim, Hae Young Montgomery, Elizabeth |
author_facet | Shin, Dong Hoon Lee, Jung Hee Kang, Hyun Jeong Choi, Kyung Un Kim, Jee Yeon Park, Do Youn Lee, Chang Hun Sol, Mee Young Park, Jae Hong Kim, Hae Young Montgomery, Elizabeth |
author_sort | Shin, Dong Hoon |
collection | PubMed |
description | Gastroblastoma is a rare gastric epitheliomesenchymal biphasic tumour composed of spindle and epithelial cells, reported by Miettinen et al in a series of three cases in 2009. All those cases arose in stomachs of young adults. Neither the epithelial nor the mesenchymal component displayed sufficient atypia to diagnose a carcinosarcoma or other malignancy. On immunohistochemistry, the epithelial component expressed cytokeratin, and the mesenchymal component was positive for vimentin and CD10. Miettinen et al designated these neoplasms as gastroblastomas based on their similarities with other childhood blastomas such as pleuropulmonary blastoma and nephroblastoma. This report describes a probable fourth case of this unique type of neoplasm. The present case arose in the gastric antrum of a 9-year-old boy. While similarities were evident with the other cases, there were some differences. The epithelial component was more predominant and showed more mature morphology. Immunohistochemically, the epithelial component showed immunolabelling for c-KIT and CD56. The mesenchymal component was only focally positive for CD10. Ultrastructually, desmosomes and microvilli were found supporting a truly epithelial lesion. |
format | Text |
id | pubmed-2922722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BMJ Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-29227222010-08-17 Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings Shin, Dong Hoon Lee, Jung Hee Kang, Hyun Jeong Choi, Kyung Un Kim, Jee Yeon Park, Do Youn Lee, Chang Hun Sol, Mee Young Park, Jae Hong Kim, Hae Young Montgomery, Elizabeth J Clin Pathol Case Report Gastroblastoma is a rare gastric epitheliomesenchymal biphasic tumour composed of spindle and epithelial cells, reported by Miettinen et al in a series of three cases in 2009. All those cases arose in stomachs of young adults. Neither the epithelial nor the mesenchymal component displayed sufficient atypia to diagnose a carcinosarcoma or other malignancy. On immunohistochemistry, the epithelial component expressed cytokeratin, and the mesenchymal component was positive for vimentin and CD10. Miettinen et al designated these neoplasms as gastroblastomas based on their similarities with other childhood blastomas such as pleuropulmonary blastoma and nephroblastoma. This report describes a probable fourth case of this unique type of neoplasm. The present case arose in the gastric antrum of a 9-year-old boy. While similarities were evident with the other cases, there were some differences. The epithelial component was more predominant and showed more mature morphology. Immunohistochemically, the epithelial component showed immunolabelling for c-KIT and CD56. The mesenchymal component was only focally positive for CD10. Ultrastructually, desmosomes and microvilli were found supporting a truly epithelial lesion. BMJ Group 2010-03-04 2010-03 /pmc/articles/PMC2922722/ /pubmed/20203230 http://dx.doi.org/10.1136/jcp.2009.074104 Text en © 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. |
spellingShingle | Case Report Shin, Dong Hoon Lee, Jung Hee Kang, Hyun Jeong Choi, Kyung Un Kim, Jee Yeon Park, Do Youn Lee, Chang Hun Sol, Mee Young Park, Jae Hong Kim, Hae Young Montgomery, Elizabeth Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings |
title | Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings |
title_full | Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings |
title_fullStr | Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings |
title_full_unstemmed | Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings |
title_short | Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings |
title_sort | novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922722/ https://www.ncbi.nlm.nih.gov/pubmed/20203230 http://dx.doi.org/10.1136/jcp.2009.074104 |
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