Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood

Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cy...

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Detalles Bibliográficos
Autores principales: Holladay, Steven D., Xiao, Shuo, Diao, Honglu, Barber, Jamie, Nagy, Tomas, Ye, Xiaoqin, Gogal, Robert M.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922731/
https://www.ncbi.nlm.nih.gov/pubmed/20717544
http://dx.doi.org/10.3390/ijerph7072845
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author Holladay, Steven D.
Xiao, Shuo
Diao, Honglu
Barber, Jamie
Nagy, Tomas
Ye, Xiaoqin
Gogal, Robert M.
author_facet Holladay, Steven D.
Xiao, Shuo
Diao, Honglu
Barber, Jamie
Nagy, Tomas
Ye, Xiaoqin
Gogal, Robert M.
author_sort Holladay, Steven D.
collection PubMed
description Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines were suggested in the adult BPA offspring. Serum showed a numeric increase in 16 of 21 basal cytokine levels. ConA-stimulated splenocytes showed a numeric increase in 17 of 21 cytokines, and LPS-stimulated splenocytes an increase in 18 of 21 cytokines. The cytokine profile was one of T(H)1 up-regulation more than T(H)2, and with skewing toward T(H)17 responses.
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spelling pubmed-29227312010-08-17 Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood Holladay, Steven D. Xiao, Shuo Diao, Honglu Barber, Jamie Nagy, Tomas Ye, Xiaoqin Gogal, Robert M. Int J Environ Res Public Health Article Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines were suggested in the adult BPA offspring. Serum showed a numeric increase in 16 of 21 basal cytokine levels. ConA-stimulated splenocytes showed a numeric increase in 17 of 21 cytokines, and LPS-stimulated splenocytes an increase in 18 of 21 cytokines. The cytokine profile was one of T(H)1 up-regulation more than T(H)2, and with skewing toward T(H)17 responses. Molecular Diversity Preservation International (MDPI) 2010-07 2010-07-12 /pmc/articles/PMC2922731/ /pubmed/20717544 http://dx.doi.org/10.3390/ijerph7072845 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Holladay, Steven D.
Xiao, Shuo
Diao, Honglu
Barber, Jamie
Nagy, Tomas
Ye, Xiaoqin
Gogal, Robert M.
Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood
title Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood
title_full Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood
title_fullStr Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood
title_full_unstemmed Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood
title_short Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood
title_sort perinatal bisphenol a exposure in c57b6/129svj male mice: potential altered cytokine/chemokine production in adulthood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922731/
https://www.ncbi.nlm.nih.gov/pubmed/20717544
http://dx.doi.org/10.3390/ijerph7072845
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