The C-terminus of p53 binds the N-terminal domain of MDM2

The p53 tumor suppressor interacts with its negative regulator Mdm2 via the former’s N-terminal region and core domain. Yet the extreme p53 C-terminal region contains lysine residues ubiquitinated by Mdm2 and can bear post-translational modifications that inhibit Mdm2–p53 association. We show that,...

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Detalles Bibliográficos
Autores principales: Poyurovsky, Masha V., Katz, Chen, Laptenko, Oleg, Beckerman, Rachel, Lokshin, Maria, Ahn, Jinwoo, Byeon, In-Ja L., Gabizon, Ronen, Mattia, Melissa, Zupnick, Andrew, Brown, Lewis M., Friedler, Assaf, Prives, Carol
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922928/
https://www.ncbi.nlm.nih.gov/pubmed/20639885
http://dx.doi.org/10.1038/nsmb.1872

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