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Herpes Simplex Virus 2 ICP0(−) Mutant Viruses Are Avirulent and Immunogenic: Implications for a Genital Herpes Vaccine
Herpes simplex virus 1 (HSV-1) ICP0 (−) mutants are interferon-sensitive, avirulent, and elicit protective immunity against HSV-1 (Virol J, 2006, 3:44). If an ICP0 (−) mutant of herpes simplex virus 2 (HSV-2) exhibited similar properties, such a virus might be used to vaccinate against genital herpe...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923193/ https://www.ncbi.nlm.nih.gov/pubmed/20808928 http://dx.doi.org/10.1371/journal.pone.0012251 |