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Herpes Simplex Virus 2 ICP0(−) Mutant Viruses Are Avirulent and Immunogenic: Implications for a Genital Herpes Vaccine

Herpes simplex virus 1 (HSV-1) ICP0 (−) mutants are interferon-sensitive, avirulent, and elicit protective immunity against HSV-1 (Virol J, 2006, 3:44). If an ICP0 (−) mutant of herpes simplex virus 2 (HSV-2) exhibited similar properties, such a virus might be used to vaccinate against genital herpe...

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Detalles Bibliográficos
Autores principales:	Halford, William P., Püschel, Ringo, Rakowski, Brandon
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923193/ https://www.ncbi.nlm.nih.gov/pubmed/20808928 http://dx.doi.org/10.1371/journal.pone.0012251

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