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Aquaporin Biology and Nervous System
Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins: the Aquaporins (AQPs). These proteins are present in organisms at all levels of life, and their unique permeability characteristics a...
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Formato: | Texto |
Lenguaje: | English |
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Bentham Science Publishers Ltd
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923373/ https://www.ncbi.nlm.nih.gov/pubmed/21119880 http://dx.doi.org/10.2174/157015910791233204 |
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author | Barbara, Buffoli |
author_facet | Barbara, Buffoli |
author_sort | Barbara, Buffoli |
collection | PubMed |
description | Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins: the Aquaporins (AQPs). These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in numerous tissues indicate diverse roles in the regulation of water homeostasis. Phenotype analysis of AQP knock-out mice has confirmed the predicted role of AQPs in osmotically driven transepithelial fluid transport, as occurs in the urinary concentrating mechanism and glandular fluid secretion. Regarding their expression in nervous system, there are evidences suggesting that AQPs are differentially expressed in the peripheral versus central nervous system and that channel-mediated water transport mechanisms may be involved in cerebrospinal fluid formation, neuronal signal transduction and information processing. Moreover, a number of recent studies have revealed the importance of mammalian AQPs in both physiological and pathophysiological mechanisms and have suggested that pharmacological modulation of AQP expression and activity may provide new tools for the treatment of variety of human disorders in which water and small solute transport may be involved. For all the AQPs, new contributions to physiological functions are likely to be discovered with ongoing work in this rapidly expanding field of research. |
format | Text |
id | pubmed-2923373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Bentham Science Publishers Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-29233732010-12-01 Aquaporin Biology and Nervous System Barbara, Buffoli Curr Neuropharmacol Article Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins: the Aquaporins (AQPs). These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in numerous tissues indicate diverse roles in the regulation of water homeostasis. Phenotype analysis of AQP knock-out mice has confirmed the predicted role of AQPs in osmotically driven transepithelial fluid transport, as occurs in the urinary concentrating mechanism and glandular fluid secretion. Regarding their expression in nervous system, there are evidences suggesting that AQPs are differentially expressed in the peripheral versus central nervous system and that channel-mediated water transport mechanisms may be involved in cerebrospinal fluid formation, neuronal signal transduction and information processing. Moreover, a number of recent studies have revealed the importance of mammalian AQPs in both physiological and pathophysiological mechanisms and have suggested that pharmacological modulation of AQP expression and activity may provide new tools for the treatment of variety of human disorders in which water and small solute transport may be involved. For all the AQPs, new contributions to physiological functions are likely to be discovered with ongoing work in this rapidly expanding field of research. Bentham Science Publishers Ltd 2010-06 /pmc/articles/PMC2923373/ /pubmed/21119880 http://dx.doi.org/10.2174/157015910791233204 Text en ©2010 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Barbara, Buffoli Aquaporin Biology and Nervous System |
title | Aquaporin Biology and Nervous System |
title_full | Aquaporin Biology and Nervous System |
title_fullStr | Aquaporin Biology and Nervous System |
title_full_unstemmed | Aquaporin Biology and Nervous System |
title_short | Aquaporin Biology and Nervous System |
title_sort | aquaporin biology and nervous system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923373/ https://www.ncbi.nlm.nih.gov/pubmed/21119880 http://dx.doi.org/10.2174/157015910791233204 |
work_keys_str_mv | AT barbarabuffoli aquaporinbiologyandnervoussystem |