Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4

The mammalian SPRY domain- and SOCS box-containing proteins, SPSB1 to SPSB4, belong to the SOCS box family of E3 ubiquitin ligases. Substrate recognition sites for the SPRY domain are identified only for human Par-4 (ELNNNL) and for the Drosophila orthologue GUSTAVUS binding to the DEAD-box RNA heli...

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Detalles Bibliográficos
Autores principales: Filippakopoulos, Panagis, Low, Andrew, Sharpe, Timothy D., Uppenberg, Jonas, Yao, Shenggen, Kuang, Zhihe, Savitsky, Pavel, Lewis, Rowena S., Nicholson, Sandra E., Norton, Raymond S., Bullock, Alex N.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923778/
https://www.ncbi.nlm.nih.gov/pubmed/20561531
http://dx.doi.org/10.1016/j.jmb.2010.06.017

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