Purified E255L Mutant SERCA1a and Purified PfATP6 Are Sensitive to SERCA-type Inhibitors but Insensitive to Artemisinins

The antimalarial drugs artemisinins have been described as inhibiting Ca(2+)-ATPase activity of PfATP6 (Plasmodium falciparum ATP6) after expression in Xenopus oocytes. Mutation of an amino acid residue in mammalian SERCA1 (Glu(255)) to the equivalent one predicted in PfATP6 (Leu) was reported to in...

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Detalles Bibliográficos
Autores principales: Cardi, Delphine, Pozza, Alexandre, Arnou, Bertrand, Marchal, Estelle, Clausen, Johannes D., Andersen, Jens Peter, Krishna, Sanjeev, Møller, Jesper V., le Maire, Marc, Jaxel, Christine
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Membrane Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924071/
https://www.ncbi.nlm.nih.gov/pubmed/20530490
http://dx.doi.org/10.1074/jbc.M109.090340

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