Moisture-induced solid state instabilities in α-chymotrypsin and their reduction through chemical glycosylation

BACKGROUND: Protein instability remains the main factor limiting the development of protein therapeutics. The fragile nature (structurally and chemically) of proteins makes them susceptible to detrimental events during processing, storage, and delivery. To overcome this, proteins are often formulate...

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Detalles Bibliográficos
Autores principales: Flores-Fernández, Giselle M, Pagán, Miraida, Almenas, Mariangely, Solá, Ricardo J, Griebenow, Kai
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924255/
https://www.ncbi.nlm.nih.gov/pubmed/20696067
http://dx.doi.org/10.1186/1472-6750-10-57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924255/
https://www.ncbi.nlm.nih.gov/pubmed/20696067
http://dx.doi.org/10.1186/1472-6750-10-57

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