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Moisture-induced solid state instabilities in α-chymotrypsin and their reduction through chemical glycosylation
BACKGROUND: Protein instability remains the main factor limiting the development of protein therapeutics. The fragile nature (structurally and chemically) of proteins makes them susceptible to detrimental events during processing, storage, and delivery. To overcome this, proteins are often formulate...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924255/ https://www.ncbi.nlm.nih.gov/pubmed/20696067 http://dx.doi.org/10.1186/1472-6750-10-57 |