Genome-Wide Profiling of p63 DNA–Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 Locus

Heterozygous mutations in p63 are associated with split hand/foot malformations (SHFM), orofacial clefting, and ectodermal abnormalities. Elucidation of the p63 gene network that includes target genes and regulatory elements may reveal new genes for other malformation disorders. We performed genome-...

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Detalles Bibliográficos
Autores principales: Kouwenhoven, Evelyn N., van Heeringen, Simon J., Tena, Juan J., Oti, Martin, Dutilh, Bas E., Alonso, M. Eva, de la Calle-Mustienes, Elisa, Smeenk, Leonie, Rinne, Tuula, Parsaulian, Lilian, Bolat, Emine, Jurgelenaite, Rasa, Huynen, Martijn A., Hoischen, Alexander, Veltman, Joris A., Brunner, Han G., Roscioli, Tony, Oates, Emily, Wilson, Meredith, Manzanares, Miguel, Gómez-Skarmeta, José Luis, Stunnenberg, Hendrik G., Lohrum, Marion, van Bokhoven, Hans, Zhou, Huiqing
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924305/
https://www.ncbi.nlm.nih.gov/pubmed/20808887
http://dx.doi.org/10.1371/journal.pgen.1001065

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