Tuberous Sclerosis Complex 1 Regulates dE2F1 Expression during Development and Cooperates with RBF1 to Control Proliferation and Survival

Previous studies in Drosophila melanogaster have demonstrated that many tumor suppressor pathways impinge on Rb/E2F to regulate proliferation and survival. Here, we report that Tuberous Sclerosis Complex 1 (TSC1), a well-established tumor suppressor that regulates cell size, is an important regulato...

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Detalles Bibliográficos
Autores principales: Hsieh, Ting-Chiu, Nicolay, Brandon N., Frolov, Maxim V., Moon, Nam-Sung
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924346/
https://www.ncbi.nlm.nih.gov/pubmed/20808898
http://dx.doi.org/10.1371/journal.pgen.1001071

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