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Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity

TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5α but they have distinct lentiviral specificities, conferring HIV-1 restriction in New World owl monkeys and HIV-2 res...

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Detalles Bibliográficos
Autores principales:	Ylinen, Laura M. J., Price, Amanda J., Rasaiyaah, Jane, Hué, Stéphane, Rose, Nicola J., Marzetta, Flavia, James, Leo C., Towers, Greg J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924388/ https://www.ncbi.nlm.nih.gov/pubmed/20808866 http://dx.doi.org/10.1371/journal.ppat.1001062

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